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Opinion|Videos|March 13, 2026

Experiences With ADCs in EGFR-Mutated NSCLC Management

Author(s)Natalie I. U. Vokes, MD, Sid Devarakonda, MBBS, MD

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, discuss clinical experience with antibody-drug conjugates in EGFR-mutated NSCLC.

Episodes in this series

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EP. 1 Risk Factors That Help Inform Treatment Selection in Frontline EGFR-Mutated NSCLC

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EP. 2 Sequencing Considerations in Advanced EGFR-Mutated NSCLC

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EP. 3 Evolving Frontline Treatment Options in EGFR-Mutated NSCLC

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EP. 4 Resistance mechanisms in EGFR-Mutated NSCLC

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EP. 5 Experiences With ADCs in EGFR-Mutated NSCLC Management

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EP. 6 Remaining Evidence Gaps in EGFR-Mutated NSCLC Care

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EP. 7 Ongoing Research to Watch in EGFR-Mutated NSCLC

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, discuss the integration of antibody-drug conjugates (ADCs) into the treatment paradigm for EGFR-mutated NSCLC. Vokes reviews clinical data supporting ADC use in previously treated disease. Devarakonda emphasizes safety considerations, including monitoring for interstitial lung disease and hematologic toxicities, when incorporating these agents.

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