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Opinion|Videos|March 13, 2026

Sequencing Considerations in Advanced EGFR-Mutated NSCLC

Author(s)Natalie I. U. Vokes, MD, Sid Devarakonda, MBBS, MD

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, discuss sequencing strategies in advanced EGFR-mutated NSCLC.

Episodes in this series

2 experts in this video

EP. 1 Risk Factors That Help Inform Treatment Selection in Frontline EGFR-Mutated NSCLC

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EP. 2 Sequencing Considerations in Advanced EGFR-Mutated NSCLC

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EP. 3 Evolving Frontline Treatment Options in EGFR-Mutated NSCLC

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EP. 4 Resistance mechanisms in EGFR-Mutated NSCLC

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EP. 5 Experiences With ADCs in EGFR-Mutated NSCLC Management

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EP. 6 Remaining Evidence Gaps in EGFR-Mutated NSCLC Care

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EP. 7 Ongoing Research to Watch in EGFR-Mutated NSCLC

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, explore optimal sequencing strategies following frontline EGFR-directed therapy in EGFR-mutated non–small cell lung cancer. Vokes reviews mechanisms of acquired resistance and the role of repeat molecular testing at progression. Devarakonda highlights how emerging targeted therapies and combination regimens may influence second- and later-line treatment planning.

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