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Opinion|Videos|March 13, 2026

Remaining Evidence Gaps in EGFR-Mutated NSCLC Care

Author(s)Natalie I. U. Vokes, MD, Sid Devarakonda, MBBS, MD

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, discuss remaining evidence gaps in EGFR-mutated NSCLC care.

Episodes in this series

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EP. 1 Risk Factors That Help Inform Treatment Selection in Frontline EGFR-Mutated NSCLC

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EP. 2 Sequencing Considerations in Advanced EGFR-Mutated NSCLC

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EP. 3 Evolving Frontline Treatment Options in EGFR-Mutated NSCLC

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EP. 4 Resistance mechanisms in EGFR-Mutated NSCLC

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EP. 5 Experiences With ADCs in EGFR-Mutated NSCLC Management

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EP. 6 Remaining Evidence Gaps in EGFR-Mutated NSCLC Care

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EP. 7 Ongoing Research to Watch in EGFR-Mutated NSCLC

Natalie Vokes, MD, and Sid Devarakonda, MBBS, MD, identify persistent evidence gaps in the management of EGFR-mutated non–small cell lung cancer. Vokes highlights unanswered questions regarding optimal combination strategies, duration of therapy, and sequencing after novel frontline regimens. Devarakonda underscores the need for biomarker-driven research and real-world data to refine treatment algorithms.

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