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News|Videos|March 6, 2025

Expert Insights: Managing Patients with PIK3CA Mutations

Author(s)Joyce O’Shaughnessy, MD, Alison Conlin, MD

Episodes in this series

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

Video content above is prompted by the following:

Dr. Conlin to Dr. O’Shaughnessy: For patients with PIK3CA mutations, how do you decide between alpelisib vs inavolisib vs capivasertib (André et al. NEJM 2019, Turner et al. NEJM 2024, Turner et al. NEJM 2023)?
- What factors guide your decision making?
- What is your impression of the incidence and need to manage hyperglycemia with these agents?
Dr. O’Shaughnessy to Dr. Conlin: If a patient progresses on 1L CDK4/6 inhibitor plus fulvestrant, do you typically switch to a different CDK4/6 inhibitor or change the endocrine therapy partner or both in the 2L setting?

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