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News|Videos|March 6, 2025

Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

Author(s)Joyce O’Shaughnessy, MD, Alison Conlin, MD

Episodes in this series

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

Video content above is prompted by the following:

Dr. O’Shaughnessy to Dr. Conlin: What is your preferred CDK4/6 regimen in the first-line metastatic setting?
- How do patient factors like visceral crisis, bone-only disease, or comorbidities influence your decision?
- What toxicity concerns inform your choice of CDK4/6 inhibitor?

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