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News|Videos|March 6, 2025

Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

Author(s)Joyce O’Shaughnessy, MD, Alison Conlin, MD

Episodes in this series

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 1 Clinical Perspectives on Biomarker Testing in mBC

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 2 Repeat Biomarker Testing in mBC: Navigating the Rapidly Evolving Treatment Landscape

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 3 Selecting the Optimal CDK4/6 Regimen for First-Line Therapy

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 4 Clinical Considerations for CDK4/6 Inhibition Beyond Progression

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 5 Expert Insights: Managing Patients with PIK3CA Mutations

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 6 Navigating Treatment Selection in Patients with Both ESR1 and PIK3CA Mutations and Expert Perspective for Integrating Oral SERDs into Clinical Practice

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 7 The Emerging Role of Triplet Therapy in mBC: Opportunities and Challenges

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

EP. 8 The Evolving Landscape of mBC Treatment: Unmet Needs and Future Predictions

Video content above is prompted by the following:

Dr. O’Shaughnessy to Dr. Conlin: What is your approach to oral SERD therapy?
- For which specific patient population would you consider using single-agent elacestrant (Bardia et al. Clin Cancer Res 2024)?
- Do you foresee elacestrant replacing fulvestrant as the endocrine therapy backbone in combination with targeted therapies?

Dr. Conlin to Dr. O’Shaughnessy: How do you decide which mutation to target in patients who harbor both an ESR1 and PIK3CA mutation?
- Do you foresee a scientific rationale for a particular sequence/s of inhibitors of the PI3K pathway?

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