Opinion|Videos|January 28, 2025
Expert Perspectives: Navigating the Emerging Treatment Landscape of Combination Therapies in TN CLL—Applying Evidence to Clinical Practice
Panelists discuss how patient-specific factors including age, comorbidities, genetic profile, and treatment goals guide the selection between doublet and triplet regimens in chronic lymphocytic leukemia (CLL), with considerations like Bruton tyrosine kinase inhibitor tolerability, desire for time-limited therapy, and high-risk features informing the choice between various BTK inhibitor–based combinations with venetoclax and obinutuzumab.
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Video content above is prompted by the following:
- For which patients would you consider a doublet vs triplet combination regimen? What factors would you consider among selecting the various triplet regimens (eg, acalabrutinib vs zanubrutinib vs pirtobrutinib plus venetoclax and obinutuzumab)?
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