Opinion|Videos|January 7, 2025
Real-World Observations: Firstline cBTKi Switches and Cardiac AEs in TN CLL
Panelists discuss how real-world treatment patterns with covalent BTK inhibitors differ from clinical trial experiences, particularly regarding the rates of discontinuation due to intolerance vs progression and the incidence of cardiac adverse events with acalabrutinib and zanubrutinib in clinical practice.
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Video content above is prompted by the following:
- What percentage of your patients switch from first-line cBTKi due to intolerance vs progression vs being refractory? How often are you observing cardiac treatment–related AEs with acala and zanu in the real-life day-to-day practice vs what has been reported in the clinical trials?
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