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Opinion|Videos|January 7, 2025

Real-World Observations: Firstline cBTKi Switches and Cardiac AEs in TN CLL

Panelists discuss how real-world treatment patterns with covalent BTK inhibitors differ from clinical trial experiences, particularly regarding the rates of discontinuation due to intolerance vs progression and the incidence of cardiac adverse events with acalabrutinib and zanubrutinib in clinical practice.

Episodes in this series

EP. 1 Expert Insights in Selecting Frontline Therapies in TN CLL: Fixed-Duration Venetoclax vs Continuous BTKi

EP. 1 Expert Insights in Selecting Frontline Therapies in TN CLL: Fixed-Duration Venetoclax vs Continuous BTKi

EP. 2 ASH 2024 Updates: SEQUOIA 5-Year Follow-Up and Expert Perspectives in Selecting Between Acalabrutinib vs Zanubrutinib in TN CLL

EP. 2 ASH 2024 Updates: SEQUOIA 5-Year Follow-Up and Expert Perspectives in Selecting Between Acalabrutinib vs Zanubrutinib in TN CLL

EP. 3 Real-World Observations: Firstline cBTKi Switches and Cardiac AEs in TN CLL

EP. 3 Real-World Observations: Firstline cBTKi Switches and Cardiac AEs in TN CLL

EP. 4 Clinical Insights: Exploring Combination Regimens in First-Line Treatment in CLL: SEQUOIA Arm D and BOVen Trials

EP. 4 Clinical Insights: Exploring Combination Regimens in First-Line Treatment in CLL: SEQUOIA Arm D and BOVen Trials

EP. 5 Key Takeaways From the AMPLIFY Trial at ASH 2024: Fixed-Duration Acalabrutinib Plus Venetoclax With or Without Obinutuzumab vs Chemoimmunotherapy in TN CLL

EP. 5 Key Takeaways From the AMPLIFY Trial at ASH 2024: Fixed-Duration Acalabrutinib Plus Venetoclax With or Without Obinutuzumab vs Chemoimmunotherapy in TN CLL

EP. 6 ASH 2024 Updates: Evaluating Potential Frontline Triplet Regimen: Pirtobrutinib Plus Venetoclax Plus Obinutuzumab in TN CLL

EP. 6 ASH 2024 Updates: Evaluating Potential Frontline Triplet Regimen: Pirtobrutinib Plus Venetoclax Plus Obinutuzumab in TN CLL

EP. 7 Expert Perspectives: Navigating the Emerging Treatment Landscape of Combination Therapies in TN CLL—Applying Evidence to Clinical Practice

EP. 7 Expert Perspectives: Navigating the Emerging Treatment Landscape of Combination Therapies in TN CLL—Applying Evidence to Clinical Practice

EP. 8 Expert Insights: Treatment Selection in Second-Line R/R CLL and Limitations of Applying MAIC Data in the Real-World Practice Setting

EP. 8 Expert Insights: Treatment Selection in Second-Line R/R CLL and Limitations of Applying MAIC Data in the Real-World Practice Setting

EP. 9 ASH 2024 Highlights: Phase 2 Study of Zanubrutinib Plus Venetoclax in R/R CLL

EP. 9 ASH 2024 Highlights: Phase 2 Study of Zanubrutinib Plus Venetoclax in R/R CLL

EP. 10 Treatment Sequencing in R/R CLL: Optimizing Strategies and Clinical Insights From ASH 2024 Real-World Data

EP. 10 Treatment Sequencing in R/R CLL: Optimizing Strategies and Clinical Insights From ASH 2024 Real-World Data

EP. 11 Pirtobrutinib in R/R CLL: Can It Be Used in the Second-Line Setting?

EP. 11 Pirtobrutinib in R/R CLL: Can It Be Used in the Second-Line Setting?

EP. 12 Sequencing Treatment in R/R CLL: CAR T-Cell Therapy vs Pirtobrutinib in Double-Exposed Patients

EP. 12 Sequencing Treatment in R/R CLL: CAR T-Cell Therapy vs Pirtobrutinib in Double-Exposed Patients

EP. 13 Real-World Observations With Pirtobrutinib and New Data From the BRUIN CLL-321 Trial at ASH 2024

EP. 13 Real-World Observations With Pirtobrutinib and New Data From the BRUIN CLL-321 Trial at ASH 2024

EP. 14 Emerging Data on BTK Inhibitor Degraders and Bispecifics in R/R CLL: Updated Results at ASH 2024

EP. 14 Emerging Data on BTK Inhibitor Degraders and Bispecifics in R/R CLL: Updated Results at ASH 2024

EP. 15 Reflecting on 2024 in CLL: Key Advances and Looking Ahead to 2025

EP. 15 Reflecting on 2024 in CLL: Key Advances and Looking Ahead to 2025

Video content above is prompted by the following:

What percentage of your patients switch from first-line cBTKi due to intolerance vs progression vs being refractory? How often are you observing cardiac treatment–related AEs with acala and zanu in the real-life day-to-day practice vs what has been reported in the clinical trials?

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