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Opinion|Videos|February 2, 2026

Interpreting ASCENT-03 and ASCENT-04: Clinical Implications for Sacituzumab Govitecan in Metastatic TNBC

Author(s)Jason Mouabbi, MD, Heather McArthur, MD, MPH, Yuan Yuan, MD, PhD

Dr. Yuan discusses the ASCENT-03 trial's efficacy, crossover implications, and safety data for sacituzumab govitecan in cancer treatment.

Episodes in this series

4 Experts are featured in this series

EP. 1 Understanding Triple-Negative Breast Cancer: Disease Overview and Defining Characteristics

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EP. 2 Evolving Treatment Strategies for Early-Stage Triple-Negative Breast Cancer

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EP. 3 Targeting TROP-2 in Triple-Negative Breast Cancer: Rationale, Agents, and Evolving Guidance

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EP. 4 Exploring Antibody–Drug Conjugates in Early-Stage TNBC: Insights from a Clinical Trial

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EP. 5 Ongoing Clinical Trials Shaping the Future of ADCs in Early Triple-Negative Breast Cancer

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EP. 6 Current Standards of Care and Evolving Segment 6 Title: Strategies in Metastatic Triple-Negative Breast Cancer

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EP. 7 Latest Clinical Evidence for TROP-2–Targeted ADCs in Metastatic Triple-Negative Breast Cance

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EP. 8 Interpreting ASCENT-03 and ASCENT-04: Clinical Implications for Sacituzumab Govitecan in Metastatic TNBC

The ASCENT-03 and ASCENT-04 trials provide important new insights into the efficacy and safety of sacituzumab govitecan (SG) in metastatic triple-negative breast cancer (TNBC) and help inform real-world treatment decisions. ASCENT-03 data highlight meaningful improvements in response durability and progression-free survival, while also raising important considerations around overall survival interpretation due to permitted crossover. Understanding endpoints such as PFS2 offers additional context on the downstream impact of SG on disease control beyond first progression. Limitations related to evolving treatment standards, including prior exposure to pembrolizumab plus chemotherapy in early-stage disease, must also be considered when applying these results to current practice. ASCENT-04 further explores SG in combination with immunotherapy, emphasizing the clinical relevance of crossover design in evaluating benefit. Real-world evidence studies provide supportive context, reinforcing the role of SG in contemporary metastatic TNBC management.

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