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Opinion|Videos|February 2, 2026

Latest Clinical Evidence for TROP-2–Targeted ADCs in Metastatic Triple-Negative Breast Cance

Author(s)Jason Mouabbi, MD, Heather McArthur, MD, MPH, Yuan Yuan, MD, PhD

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Episodes in this series

4 Experts are featured in this series

EP. 1 Understanding Triple-Negative Breast Cancer: Disease Overview and Defining Characteristics

4 Experts are featured in this series

EP. 2 Evolving Treatment Strategies for Early-Stage Triple-Negative Breast Cancer

4 Experts are featured in this series

EP. 3 Targeting TROP-2 in Triple-Negative Breast Cancer: Rationale, Agents, and Evolving Guidance

4 Experts are featured in this series

EP. 4 Exploring Antibody–Drug Conjugates in Early-Stage TNBC: Insights from a Clinical Trial

4 Experts are featured in this series

EP. 5 Ongoing Clinical Trials Shaping the Future of ADCs in Early Triple-Negative Breast Cancer

4 Experts are featured in this series

EP. 6 Current Standards of Care and Evolving Segment 6 Title: Strategies in Metastatic Triple-Negative Breast Cancer

4 Experts are featured in this series

EP. 7 Latest Clinical Evidence for TROP-2–Targeted ADCs in Metastatic Triple-Negative Breast Cance

4 Experts are featured in this series

EP. 8 Interpreting ASCENT-03 and ASCENT-04: Clinical Implications for Sacituzumab Govitecan in Metastatic TNBC

Recent clinical trial data continue to strengthen the role of TROP-2–targeted antibody–drug conjugates (ADCs) in the treatment of metastatic triple-negative breast cancer (TNBC). Studies evaluating sacituzumab govitecan, including ASCENT-03 and ASCENT-04, have further clarified its efficacy compared with chemotherapy, both as monotherapy and in combination with pembrolizumab in PD-L1–positive patients. These trials also provide important insights into adverse event profiles, helping clinicians better anticipate and manage treatment-related toxicities. Emerging data for datopotamab deruxtecan from TROPION-Breast02 highlight the activity of next-generation ADCs in heavily pretreated populations. Additionally, results from OptiTROP-Breast01 and OptiTROP-Breast02 support the potential role of sacituzumab tirumotecan as an alternative TROP-2–directed option. Collectively, these findings are shaping treatment selection and sequencing in metastatic TNBC.

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