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Opinion|Videos|January 19, 2026

Targeting TROP-2 in Triple-Negative Breast Cancer: Rationale, Agents, and Evolving Guidance

Author(s)Jason Mouabbi, MD, Heather McArthur, MD, MPH, Yuan Yuan, MD, PhD

Explore the evolving treatment landscape for early-stage triple-negative breast cancer, highlighting innovative therapies and clinical trial insights.

Episodes in this series

4 Experts are featured in this series

EP. 1 Understanding Triple-Negative Breast Cancer: Disease Overview and Defining Characteristics

4 Experts are featured in this series

EP. 2 Evolving Treatment Strategies for Early-Stage Triple-Negative Breast Cancer

4 Experts are featured in this series

EP. 3 Targeting TROP-2 in Triple-Negative Breast Cancer: Rationale, Agents, and Evolving Guidance

4 Experts are featured in this series

EP. 4 Exploring Antibody–Drug Conjugates in Early-Stage TNBC: Insights from a Clinical Trial

TROP-2 has emerged as an important therapeutic target in oncology due to its high and consistent expression across many epithelial cancers, including triple-negative breast cancer (TNBC). Its role in tumor growth, invasion, and proliferation provides a strong biologic rationale for the development of TROP-2–targeted antibody–drug conjugates (ADCs), which enable selective delivery of potent cytotoxic payloads to cancer cells. Several TROP-2–directed ADCs are particularly relevant in TNBC, including sacituzumab govitecan, datopotamab deruxtecan, and the investigational agent sacituzumab tirumotecan. Among these, sacituzumab govitecan has established a defined role in treatment guidelines for advanced TNBC, while newer agents are being evaluated across earlier lines of therapy. As clinical evidence continues to mature, guideline recommendations are evolving and are expected to further refine patient selection and sequencing of TROP-2–targeted therapies.

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