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Opinion|Videos|December 16, 2024

Lung LCNEC Disease Histology and Prognosis

Author(s)Martin Dietrich, MD, PhD, Soo-Ryum Yang, MD

Panelists discuss the typical treatment approach for patients with lung large cell neuroendocrine carcinoma (LCNEC), the patient-specific factors considered in first-line treatment selection, insights from the ASCO 2024 retrospective studies on first-line systemic treatment outcomes, and key considerations for choosing a second-line treatment strategy.

Episodes in this series

EP. 1 Lung Large Cell Neuroendocrine Carcinoma: A Rare but Aggressive Disease Intro

EP. 1 Lung Large Cell Neuroendocrine Carcinoma: A Rare but Aggressive Disease Intro

EP. 2 An Overview of the Molecular Characterization of Lung LCNEC

EP. 2 An Overview of the Molecular Characterization of Lung LCNEC

EP. 3 The Pathological Diagnosis of Lung LCNEC

EP. 3 The Pathological Diagnosis of Lung LCNEC

EP. 4 Biomarker Testing Strategies for Lung LCNEC

EP. 4 Biomarker Testing Strategies for Lung LCNEC

EP. 5 Biopsy Best Practices: Diagnosing Lung LCNEC

EP. 5 Biopsy Best Practices: Diagnosing Lung LCNEC

EP. 6 Lung LCNEC Diagnostic Challenges

EP. 6 Lung LCNEC Diagnostic Challenges

EP. 7 A Multidisciplinary Approach to Managing Lung LCNEC

EP. 7 A Multidisciplinary Approach to Managing Lung LCNEC

EP. 8 Lung LCNEC Disease Histology and Prognosis

EP. 8 Lung LCNEC Disease Histology and Prognosis

EP. 9 The Role of DLL3 in LCNEC of the Lung

EP. 9 The Role of DLL3 in LCNEC of the Lung

EP. 10 Insights on the LANCE Pilot Study on Lung LCNEC

EP. 10 Insights on the LANCE Pilot Study on Lung LCNEC

EP. 11 Novel Targeted Therapies for LCNEC of the Lung

EP. 11 Novel Targeted Therapies for LCNEC of the Lung

EP. 12 Overview of Studies of BI 764532 for Lung LCNEC

EP. 12 Overview of Studies of BI 764532 for Lung LCNEC

EP. 13 Insights Into Ongoing Investigational Studies in Lung LCNEC

EP. 13 Insights Into Ongoing Investigational Studies in Lung LCNEC

EP. 14 Potential Next-Generation Therapies for Lung LCNEC

EP. 14 Potential Next-Generation Therapies for Lung LCNEC

EP. 15 Unmet Needs in LCNEC

EP. 15 Unmet Needs in LCNEC

Given the limited therapeutic options for patients with lung LCNEC, what is your typical treatment approach?
- What patient-specific factors do you consider to guide your first-line treatment selection?
Please share your thoughts on the ASCO 2024 retrospective studies examining first-line systemic treatment outcomes: 1. (Nassar et al, ASCO 2024); 2. (Matteson et al., ASCO 2024)
- What are your key considerations for choosing a second-line treatment strategy?
- How has the tarlatamab approval in SCLC(Ahn et al., NEJM 2023) impacted your treatment approach for patients with LCNEC?

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