|Videos|September 16, 2020

Metastatic HR+ Breast Cancer

Author(s)Sarah Sammons, MD, Duke Cancer Institute, Julie Collins, MD, MedStar Georgetown University Hospital, Kelly McCann, MD, PhD, Ronald Reagan UCLA Medical Center

Sarah Sammons, MD, and Julie Collins, MD, discuss the study details of the PARSIFAL and BYLieve trials in patients with metastatic HR+ breast cancer.

Data from the following clinical trials are discussed:

PARSIFAL: A randomized, multicenter, open-label, phase II trial to evaluate palbociclib in combination with fulvestrant or letrozole in endocrine-sensitive patients with ER[+]/HER2[-] metastatic breast cancer. (Llombart-Cussac A et al. 2020 ASCO annual meeting. Abstract 1007.)
Alpelisib + fulvestrant in patients with PIK3CA-mutated HR+/HER2- advanced breast cancer previously treated with CDK4/6 inhibitor + aromatase inhibitor: BYLieve study results. (Rugo HS et al. 2020 ASCO annual meeting. Abstract 1006.)

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Metastatic HR+ Breast Cancer

Data from the following clinical trials are discussed:

PARSIFAL: A randomized, multicenter, open-label, phase II trial to evaluate palbociclib in combination with fulvestrant or letrozole in endocrine-sensitive patients with ER[+]/HER2[-] metastatic breast cancer. (Llombart-Cussac A et al. 2020 ASCO annual meeting. Abstract 1007.)

Alpelisib + fulvestrant in patients with PIK3CA-mutated HR+/HER2- advanced breast cancer previously treated with CDK4/6 inhibitor + aromatase inhibitor: BYLieve study results. (Rugo HS et al. 2020 ASCO annual meeting. Abstract 1006.)

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