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Opinion|Videos|July 22, 2024

Overview of DESTINY-Breast06

Author(s)Joyce A. O'Shaughnessy, MD, Melinda L. Telli, MD, Aditya Bardia, MD, MPH, FASCO

Aditya Bardia, MD, MPH, shares comprehensive insights on the DESTINY-Breast06 study evaluating T-DXd in HER2-low and HER2 ultra-low metastatic breast cancer, and the panel offers its initial impressions.

Episodes in this series

A panel of 5 experts on breast cancer

EP. 1 Challenges in Diagnosing HER2+ Breast Cancer

A panel of 5 experts on breast cancer

EP. 2 Neoadjuvant Treatment Options in HER2+ Early Breast Cancer

A panel of 5 experts on breast cancer

EP. 3 Preoperative Monitoring and Surgical Options for HER2+ Patients

A panel of 5 experts on breast cancer

EP. 4 Clinical Impact of Subcutaneous Fixed-Dose Pertuzumab – trastuzumab-hyaluronidase in HER2+ Breast Cancer

A panel of 5 experts on breast cancer

EP. 5 Standard-of-Care Regimens for First-Line Treatment of HER2+ mBC

A panel of 5 experts on breast cancer

EP. 6 Ongoing Clinical Trials in HER2+ Metastatic Breast Cancer

A panel of 5 experts on breast cancer

EP. 7 Impact of DESTINY-Breast09 and Other Trials on Clinical Practice and Patient Subsets

A panel of 5 experts on breast cancer

EP. 8 Defining HER2 Low and HER2 Ultra-Low: Diagnostic Challenges

A panel of 5 experts on breast cancer

EP. 9 Overview of DESTINY-Breast06

A panel of 5 experts on breast cancer

EP. 10 Clinical Perspectives on Managing ILD Related to T-DXd

A panel of 5 experts on breast cancer

EP. 11 Clinical Considerations and Subsequent Therapies or Sequencing in HER2-Low/HER2+ mBC

A panel of 5 experts on breast cancer

EP. 12 Unmet Needs and Future Direction in HER2+ Breast Cancer

Video content above is prompted by the following questions:

Briefly discuss the DESTINY-Breast06, including study design, primary endpoints, and safety:
- DESTINY-Breast06 evaluating T-DXd vs investigators choice of chemotherapy in HER2-low, HR+ mBC.
  - Based on the above data, how might this impact practice patterns in HER2-low and HER2 ultra-low disease?
  - Would the avail of first-line T-DXd for HER2-low and HER2 ultra-low patients influence your approach in the number of regimens of endocrine therapy you recommend to patients?

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