Your AI-Trained Oncology Knowledge Connection!
Opinion
Video
Navigating FGFRi Therapy Adverse Effects: Nail Toxicities
Author(s):
Experts share preventative and management strategies for nail toxicities and mouth sores that can cause significant quality of life issues for patients being treated with FGFRi.
This page is funded by Taiho Oncology, Inc. The faculty and publisher are solely responsible for this content. Taiho does not recommend or endorse the use of its products other than as described in the approved labeling. The content of this page is not medical advice and does not replace independent medical judgment.
This is a video synopsis/summary of an OncLive Insights involving Lipika Goyal, MD; Chaundra Bishop; R. Katie Kelley, MD; and Caroline Kuhlman, NP.
Nail toxicity is a nearly universal adverse effect of FGFR inhibitors such as pemigatinib and futibatinib. Changes range from mild thickening and ridging to severe onycholysis (nail detachment) or complete nail loss, usually starting after 3 to 6 months on treatment. The fragmented, thickened nails can become painful, foul smelling, and embarrassing. Cracking around the nailbeds also risks bacterial or fungal infections such as paronychia. Patients should be warned to expect nail changes. To help mitigate issues, nails should be kept clean with vinegar soaks and antimicrobial ointments/solutions. Oral or topical antibiotics can treat infections. Dead nail material can be removed to prevent catching and discomfort. By 6 to 8 months after nail toxicity begins, most patients have complete nail loss, leaving only the matrix, which is often better tolerated than the fragmentation phase.
Video synopsis is AI-generated and reviewed by OncLive® editorial staff.
