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Opinion|Videos|November 18, 2025

Novel CAR T Strategies Under Investigation for Follicular Lymphoma

Author(s)Reem Karmali, MD, MS, Sairah Ahmed, MD

Panelists discuss how novel CAR T strategies are being studied to further improve outcomes in follicular lymphoma.

Episodes in this series

$EP. 1 Current Treatment Landscape in Relapsed/Refractory Follicular Lymphoma$

EP. 1 Current Treatment Landscape in Relapsed/Refractory Follicular Lymphoma

$EP. 2 Preferred Second-Line Treatment Strategies in Relapsed/Refractory Follicular Lymphoma$

EP. 2 Preferred Second-Line Treatment Strategies in Relapsed/Refractory Follicular Lymphoma

EP. 3 Benefits and Limits of Early-Line Treatments in Follicular Lymphoma

EP. 3 Benefits and Limits of Early-Line Treatments in Follicular Lymphoma

$EP. 4 Integrating CAR T and Bispecific Antibodies in Treatments of Relapsed/Refractory Follicular Lymphoma$

EP. 4 Integrating CAR T and Bispecific Antibodies in Treatments of Relapsed/Refractory Follicular Lymphoma

$EP. 5 Clinical Considerations for CAR T Use in Relapsed/Refractory Follicular Lymphoma$

EP. 5 Clinical Considerations for CAR T Use in Relapsed/Refractory Follicular Lymphoma

$EP. 6 Pivotal Clinical Trial Evidence Supporting CAR T Use in Relapsed/Refractory Follicular Lymphoma$

EP. 6 Pivotal Clinical Trial Evidence Supporting CAR T Use in Relapsed/Refractory Follicular Lymphoma

$EP. 7 Clinical and Disease Factors Influencing CAR T Effectiveness in Relapsed/Refractory Follicular Lymphoma$

EP. 7 Clinical and Disease Factors Influencing CAR T Effectiveness in Relapsed/Refractory Follicular Lymphoma

$EP. 8 Determining the Optimal Timing of CAR T in Relapsed/Refractory Follicular Lymphoma$

EP. 8 Determining the Optimal Timing of CAR T in Relapsed/Refractory Follicular Lymphoma

$EP. 9 Factors Guiding Therapy Choice: CAR T vs Bispecific Antibodies in Relapsed/Refractory Follicular Lymphoma$

EP. 9 Factors Guiding Therapy Choice: CAR T vs Bispecific Antibodies in Relapsed/Refractory Follicular Lymphoma

$EP. 10 Safety Considerations for CAR T Versus Bispecific Antibody Therapies in Relapsed/Refractory Follicular Lymphoma$

EP. 10 Safety Considerations for CAR T Versus Bispecific Antibody Therapies in Relapsed/Refractory Follicular Lymphoma

$EP. 11 Toxicities and Risk Mitigation: Comparing CAR T Therapies in Relapsed/Refractory Follicular Lymphoma$

EP. 11 Toxicities and Risk Mitigation: Comparing CAR T Therapies in Relapsed/Refractory Follicular Lymphoma

EP. 12 Novel CAR T Strategies Under Investigation for Follicular Lymphoma

EP. 12 Novel CAR T Strategies Under Investigation for Follicular Lymphoma

$EP. 13 Current Treatment Landscape in Relapsed/Refractory Marginal Zone Lymphoma$

EP. 13 Current Treatment Landscape in Relapsed/Refractory Marginal Zone Lymphoma

$EP. 14 Unmet Clinical Needs in Relapsed/Refractory Marginal Zone Lymphoma$

EP. 14 Unmet Clinical Needs in Relapsed/Refractory Marginal Zone Lymphoma

EP. 15 Efficacy and Safety Data for CAR T Therapies in Marginal Zone Lymphoma

EP. 15 Efficacy and Safety Data for CAR T Therapies in Marginal Zone Lymphoma

EP. 16 Positioning CAR T Therapy in Marginal Zone Lymphoma: Efficacy, Safety, and Comparative Insights

EP. 16 Positioning CAR T Therapy in Marginal Zone Lymphoma: Efficacy, Safety, and Comparative Insights

Research into next-generation CAR T therapies aims to enhance safety, durability, and accessibility. Scientists are exploring new targets beyond traditional markers and developing dual-targeted CAR T cells to overcome resistance. These innovative designs may help prevent relapse and offer broader benefits to patients who have already undergone multiple treatments.

Ongoing clinical trials are testing modified CAR T constructs that enhance persistence and reduce immune-related adverse effects. Combining CAR T with other immune therapies may also create synergistic effects, deepening responses while shortening recovery times. The goal is to maintain effectiveness while improving tolerability and expanding access to more patients.

These advancements represent a growing frontier in personalized cancer care. Each improvement brings the medical community closer to making CAR T therapy safer, faster, and more widely available for individuals living with follicular lymphoma.

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