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Opinion|Videos|December 4, 2025

Positioning CAR T Therapy in Marginal Zone Lymphoma: Efficacy, Safety, and Comparative Insights

Author(s)Reem Karmali, MD, MS, Sairah Ahmed, MD

Panelists discuss how CAR T therapy is being positioned within the treatment paradigm for marginal zone lymphoma based on emerging efficacy and safety data.

Episodes in this series

$EP. 1 Current Treatment Landscape in Relapsed/Refractory Follicular Lymphoma$

EP. 1 Current Treatment Landscape in Relapsed/Refractory Follicular Lymphoma

$EP. 2 Preferred Second-Line Treatment Strategies in Relapsed/Refractory Follicular Lymphoma$

EP. 2 Preferred Second-Line Treatment Strategies in Relapsed/Refractory Follicular Lymphoma

EP. 3 Benefits and Limits of Early-Line Treatments in Follicular Lymphoma

EP. 3 Benefits and Limits of Early-Line Treatments in Follicular Lymphoma

$EP. 4 Integrating CAR T and Bispecific Antibodies in Treatments of Relapsed/Refractory Follicular Lymphoma$

EP. 4 Integrating CAR T and Bispecific Antibodies in Treatments of Relapsed/Refractory Follicular Lymphoma

$EP. 5 Clinical Considerations for CAR T Use in Relapsed/Refractory Follicular Lymphoma$

EP. 5 Clinical Considerations for CAR T Use in Relapsed/Refractory Follicular Lymphoma

$EP. 6 Pivotal Clinical Trial Evidence Supporting CAR T Use in Relapsed/Refractory Follicular Lymphoma$

EP. 6 Pivotal Clinical Trial Evidence Supporting CAR T Use in Relapsed/Refractory Follicular Lymphoma

$EP. 7 Clinical and Disease Factors Influencing CAR T Effectiveness in Relapsed/Refractory Follicular Lymphoma$

EP. 7 Clinical and Disease Factors Influencing CAR T Effectiveness in Relapsed/Refractory Follicular Lymphoma

$EP. 8 Determining the Optimal Timing of CAR T in Relapsed/Refractory Follicular Lymphoma$

EP. 8 Determining the Optimal Timing of CAR T in Relapsed/Refractory Follicular Lymphoma

$EP. 9 Factors Guiding Therapy Choice: CAR T vs Bispecific Antibodies in Relapsed/Refractory Follicular Lymphoma$

EP. 9 Factors Guiding Therapy Choice: CAR T vs Bispecific Antibodies in Relapsed/Refractory Follicular Lymphoma

$EP. 10 Safety Considerations for CAR T Versus Bispecific Antibody Therapies in Relapsed/Refractory Follicular Lymphoma$

EP. 10 Safety Considerations for CAR T Versus Bispecific Antibody Therapies in Relapsed/Refractory Follicular Lymphoma

$EP. 11 Toxicities and Risk Mitigation: Comparing CAR T Therapies in Relapsed/Refractory Follicular Lymphoma$

EP. 11 Toxicities and Risk Mitigation: Comparing CAR T Therapies in Relapsed/Refractory Follicular Lymphoma

EP. 12 Novel CAR T Strategies Under Investigation for Follicular Lymphoma

EP. 12 Novel CAR T Strategies Under Investigation for Follicular Lymphoma

$EP. 13 Current Treatment Landscape in Relapsed/Refractory Marginal Zone Lymphoma$

EP. 13 Current Treatment Landscape in Relapsed/Refractory Marginal Zone Lymphoma

$EP. 14 Unmet Clinical Needs in Relapsed/Refractory Marginal Zone Lymphoma$

EP. 14 Unmet Clinical Needs in Relapsed/Refractory Marginal Zone Lymphoma

EP. 15 Efficacy and Safety Data for CAR T Therapies in Marginal Zone Lymphoma

EP. 15 Efficacy and Safety Data for CAR T Therapies in Marginal Zone Lymphoma

EP. 16 Positioning CAR T Therapy in Marginal Zone Lymphoma: Efficacy, Safety, and Comparative Insights

EP. 16 Positioning CAR T Therapy in Marginal Zone Lymphoma: Efficacy, Safety, and Comparative Insights

Panelists discuss how CAR T therapy is increasingly recognized as a valuable addition to the treatment landscape for marginal zone lymphoma. Compared with conventional therapies, CAR T offers deeper and more durable responses for patients whose disease has returned or resisted prior treatments. The ability to harness a patient’s own immune system for long-term disease control represents a paradigm shift in care.

Comparative data suggest that CAR T therapy delivers strong efficacy while maintaining an acceptable safety profile when administered in experienced centers. By refining patient selection and supportive care, clinicians can maximize benefit while minimizing risk.

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