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Opinion|Videos|January 1, 2025

Overview of PRIMA - Niraparib 1L Maintenance

Author(s)Thomas J. Herzog, MD, John Chan, MD

Panelists discuss the implications of PFS and OS data from the PRIMA trial evaluating niraparib as first-line maintenance therapy in advanced ovarian cancer, and the impact of these findings on the treatment paradigm, as well as new insights from the GEICO-88R study on long-term responders to niraparib. They also explore emerging maintenance strategies, including IO combination therapies and hormonal therapies, with a focus on ongoing trials such as rucaparib plus nivolumab, atezolizumab plus bevacizumab, and olaparib plus cediranib.

Episodes in this series

EP. 1 Biomarker Testing in Advanced Ovarian Cancer

EP. 1 Biomarker Testing in Advanced Ovarian Cancer

EP. 2 Role of Genomic Instability Scores in Treatment Selection

EP. 2 Role of Genomic Instability Scores in Treatment Selection

EP. 3 Brief Overview of Frontline Maintenance Therapy for Advanced Ovarian Cancer

EP. 3 Brief Overview of Frontline Maintenance Therapy for Advanced Ovarian Cancer

EP. 4 Optimizing PARP Inhibitor Duration

EP. 4 Optimizing PARP Inhibitor Duration

EP. 5 Overview of PRIMA - Niraparib 1L Maintenance

EP. 5 Overview of PRIMA - Niraparib 1L Maintenance

EP. 6 Emerging Maintenance Strategies in Advanced/Metastatic Disease: Insights on Combination Therapies and Overcoming PARP Inhibitor Resistance

EP. 6 Emerging Maintenance Strategies in Advanced/Metastatic Disease: Insights on Combination Therapies and Overcoming PARP Inhibitor Resistance

EP. 7 Adverse Event Management and Emerging Therapies in Ovarian Cancer: PARPi Challenges and the Role of ADCs

EP. 7 Adverse Event Management and Emerging Therapies in Ovarian Cancer: PARPi Challenges and the Role of ADCs

Video content above is prompted by the following:

Dr Chan to ask Dr Herzog: Briefly comment on PFS and OS data from the PRIMA trial, evaluating niraparib first-line maintenance therapy in newly diagnosed advanced ovarian cancer.

What implications do these findings have, and what impact may they have on the treatment paradigm for ovarian cancer?
What new insights can be drawn about long-term responders to maintenance niraparib from the recent subanalysis of the GEICO-88R study?

Dr Herzog: What new maintenance strategies (eg, IO combination therapy or hormonal maintenance therapy) are being explored for advanced/metastatic disease?

Dr Chan to address: Rucaparib plus nivolumab (Monk B, et al. ESMO 2024. Abs LBA30)
Dr Herzog to address: Atezolizumab plus bevacizumab (Kurtz JE, et al. ESMO 2024. Abs 712MO)
Dr Chan to address:Olaparib plus cediranib ( Nicum S, et al. ESMO 2024. LBA33)
Dr Herzog to address: Other clinical trials that are being explored in combination therapy

Dr Herzog to ask Dr Chan: In which patients may you consider the above combination approaches?

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