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Opinion|Videos|December 11, 2024

Role of Genomic Instability Scores in Treatment Selection

Author(s)Thomas J. Herzog, MD, John Chan, MD

Panelists discuss how genomic instability scores, including HRD vs HRP profiles, influence treatment selection and sequencing in ovarian cancer, particularly in guiding the use of PARP inhibitors and other targeted therapies in the maintenance setting, and how these scores may prompt adjustments to standard treatment approaches.

Episodes in this series

EP. 1 Biomarker Testing in Advanced Ovarian Cancer

EP. 1 Biomarker Testing in Advanced Ovarian Cancer

EP. 2 Role of Genomic Instability Scores in Treatment Selection

EP. 2 Role of Genomic Instability Scores in Treatment Selection

EP. 3 Brief Overview of Frontline Maintenance Therapy for Advanced Ovarian Cancer

EP. 3 Brief Overview of Frontline Maintenance Therapy for Advanced Ovarian Cancer

EP. 4 Optimizing PARP Inhibitor Duration

EP. 4 Optimizing PARP Inhibitor Duration

EP. 5 Overview of PRIMA - Niraparib 1L Maintenance

EP. 5 Overview of PRIMA - Niraparib 1L Maintenance

EP. 6 Emerging Maintenance Strategies in Advanced/Metastatic Disease: Insights on Combination Therapies and Overcoming PARP Inhibitor Resistance

EP. 6 Emerging Maintenance Strategies in Advanced/Metastatic Disease: Insights on Combination Therapies and Overcoming PARP Inhibitor Resistance

EP. 7 Adverse Event Management and Emerging Therapies in Ovarian Cancer: PARPi Challenges and the Role of ADCs

EP. 7 Adverse Event Management and Emerging Therapies in Ovarian Cancer: PARPi Challenges and the Role of ADCs

Video content above is prompted by the following:

1. Dr Chan to ask Dr Herzog: How do genomic instability scores influence treatment selection and sequencing in ovarian cancer, particularly for patients with HRD vs HRP profiles?

In what ways do these scores guide the use of PARP inhibitors or other targeted therapies in the maintenance setting?
Are there scenarios where genomic instability scores might lead you to modify your standard approach to treatment?

2. Dr Herzog to ask Dr Chan: Please comment on any challenges when treating the HRP patient population

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