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Opinion|Videos|January 28, 2026

Real World Evidence and Mechanistic Rationale for Nalirifox in Metastatic Pancreatic Ductal Adenocarcinoma

Author(s)Dan Zhao, MD, PhD , Axel Grothey, MD, Jonathan Lee, MD, MSc

Experts discuss the importance of real-world data in pancreatic cancer treatment, highlighting its impact on patient management and survival outcomes.

Episodes in this series

Experts featured in this series.

EP. 1 Evolving First Line Treatment Selection in Metastatic Pancreatic Ductal Adenocarcinoma

Experts featured in this series.

EP. 2 Interpreting NAPOLI 3 Data and the Clinical Meaning of Dose Modifications in Metastatic Pancreatic Cancer

Experts featured in this series.

EP. 3 Real World Evidence and Mechanistic Rationale for Nalirifox in Metastatic Pancreatic Ductal Adenocarcinoma

Experts featured in this series.

EP. 4 Comparative Clinical Outcomes With Nalirifox and FOLFIRINOX in Metastatic Pancreatic Ductal Adenocarcinoma

In this section, faculty discuss how real world evidence complements randomized clinical trial data when selecting therapy for metastatic pancreatic ductal adenocarcinoma. Panelists describe how real world analyses, including external comparator studies help validate trial findings across broader and more heterogeneous patient populations.

The conversation then shifts to the mechanistic differences between liposomal irinotecan and conventional irinotecan. Faculty explain how the liposomal formulation alters pharmacokinetics, tissue distribution, and drug exposure, potentially contributing to differences in efficacy and tolerability observed in practice.

By integrating real world outcomes with mechanistic understanding, this segment provides clinicians with a more complete rationale for how and why Nalirifox may differ from FOLFIRINOX in everyday care. Faculty emphasize that combining biologic insight with real world data strengthens confidence in treatment selection and supports individualized decision making.

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