Subcutaneous Isatuximab via On-Body Injector Has Noninferior Efficacy vs IV Delivery in Myeloma: With Sikander Ailawadhi, MD; and Beth Faiman, CNP, PhD

Welcome to OncLive On Air^®! I’m your host today, Ashling Wahner.

OncLive On Air is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, the discussion features Sikander Ailawadhi, MD, and Beth Faiman, CNP, PhD, who provided clinical perspectives on the ongoing development of subcutaneous isatuximab-irfc (Sarclisa) administration via an on-body injector for patients with multiple myeloma. Dr Ailawadhi is a professor of medicine, a consultant in the Division of Hematology/Oncology in the Department of Internal Medicine, and a consultant in the Department of Cancer Biology at the Mayo Clinic Comprehensive Cancer Center in Jacksonville, Florida. Dr Faiman is a nurse practitioner in the Department of Hematology/Oncology at Cleveland Clinic and a member of the Cancer Prevention, Control and Population Research Program at the Case Comprehensive Cancer Center, both in Cleveland, Ohio.

In the interview, Drs Ailawadhi and Faiman reviewed findings from the phase 3 IRAKLIA study (NCT05405166), which showed that subcutaneous isatuximab delivered with an on-body injector was noninferior to intravenous isatuximab regarding efficacy, including overall response rate; pharmacokinetics; and toxicity profiles; alongside higher patient satisfaction rates. The conversation also explored practical implications for these data, including device reliability, administration efficiency, subgroup analyses assessing delivery across extremes of body weight and body mass index, and early feasibility considerations for nurse-facilitated home administration as a potential step toward more patient-centric biologic therapy delivery.

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