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Opinion|Videos|December 6, 2024

Timeline of Enfortumab Vedotin in UC: From Previously Treated UC to Frontline Therapy

Author(s)Thomas Powles MBBS, MRCP, MD

Thomas Powles, MBBS, MRCP, MD, discusses how antibody-drug conjugates have demonstrated improvement over chemotherapy. Data from the EV-301 trial shows that the antibody-drug conjugate enfortumab vedotin decreased the risk of death by 30% versus chemotherapy. Later trial data showed that treatment using enfortumab vedotin plus pembrolizumab (EV+P) reduced the risk of patient death by 53%.

Episodes in this series

1 expert in this video

EP. 1 Outlining the Current First-Line Treatment Landscape in Metastatic Urothelial Cancer: Starting With a Cisplatin-Ineligible Patient Case

1 expert in this video

EP. 2 Single-Agent Immune Therapy in UC: The Need for More

1 expert in this video

EP. 3 KEYNOTE-361 Highlights: Challenges and Insights

1 expert in this video

EP. 4 Challenges With Avelumab Maintenance in Bladder Cancer and Introduction to ADCs in UC

1 expert in this video

EP. 5 Timeline of Enfortumab Vedotin in UC: From Previously Treated UC to Frontline Therapy

1 expert in this video

EP. 6 Final Clinical Perspectives: EV+P is the New Standard of Care in Frontline Treatment of UC

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