To start our conversation, how prevalent is MDS? What are common symptoms patients may present with? Can you share how you diagnose and classify MDS? Please comment on common differential diagnoses & tests typically used for MDS diagnosis. Please comment on the risk stratification tools IPSS-M and if you have adapted using this stratification tool in your practice. What do you are share to your patients in terms of prognosis for those with lower-risk MDS? What are some current challenges for treating lower-risk MDS?