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Opinion|Videos|November 4, 2024

Imetelstat and IMerge Trial Review

Author(s)James K. McCloskey, MD, John Theurer Cancer Center, Thomas W. LeBlanc, MD, MA

Panelists discuss how imetelstat, a telomerase inhibitor recently approved by the FDA on June 6, 2024, works and its efficacy as demonstrated in the IMerge trial, while highlighting key adverse events that community oncologists should be vigilant about when considering this treatment for patients with lower-risk MDS.

Episodes in this series

2 KOLs are featured in this series.

EP. 1 Understanding Myelodysplastic Syndromes (MDS): Diagnosis, Classification, and Risk Assessment

2 KOLs are featured in this series.

EP. 2 Navigating the Heterogeneity of LR-MDS: Importance of Molecular Testing & Risk Stratifying

2 KOLs are featured in this series.

EP. 3 Clinical Scenario 1: 76-Year-Old Man With Newly Diagnosed MDS With Symptomatic Anemia, RS Positive

2 KOLs are featured in this series.

EP. 4 Tailoring Treatment for LR-MDS: Patient Factors, Treatment Goals, and Patient Outcomes

2 KOLs are featured in this series.

EP. 5 First-Line Luspatercept in LR-MDS: A Deep Dive Into the COMMANDS Trial and Clinical Implications in the Real-Life Practice Setting

2 KOLs are featured in this series.

EP. 6 Managing Luspatercept Therapy: Dosing, Adverse Effects, and Monitoring

2 KOLs are featured in this series.

EP. 7 Second-Line LR- MDS Setting: Treatment Options and Considerations

2 KOLs are featured in this series.

EP. 8 Patient Profile: 66-Year-Old Woman with Newly Diagnosed LR-MDS, RS Negative

2 KOLs are featured in this series.

EP. 9 Luspatercept Role in the RS-Negative Population and Expert Perspectives on the Role of EPO Levels

2 KOLs are featured in this series.

EP. 10 First-Line ESA vs Luspatercept in LR-MDS: Choosing the Most Appropriate Treatment Option for Each Individual Patient

2 KOLs are featured in this series.

EP. 11 Imetelstat and IMerge Trial Review

2 KOLs are featured in this series.

EP. 12 Looking Ahead in LR-MDS: Future Agents and/or Combination Strategies

2 KOLs are featured in this series.

EP. 13 The Future of Lower-Risk MDS: Closing Thoughts and Unmet Needs

Video content above is prompted by the following:

Please review imetelstat, including mechanism of action and FDA approval (imetelstat, June 6, 2024).
IMerge trial (Platzbecker U, et al. Lancet. 2024;403(10423):249-260.)
What are some key adverse events community oncologists should be aware of with imetelstat?

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