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Opinion|Videos|October 15, 2024

Managing Luspatercept Therapy: Dosing, Adverse Effects, and Monitoring

Author(s)James K. McCloskey, MD, John Theurer Cancer Center, Thomas W. LeBlanc, MD, MA

Panelists discuss how they approach luspatercept dosing strategies in clinical practice; manage treatment-related adverse events such as fatigue, hypertension, and diarrhea; and monitor labs for signs of relapse, while also considering real-world dose escalation outcomes and the correlation between peripheral blood and bone marrow biopsy mutations in patients with MDS.

Episodes in this series

2 KOLs are featured in this series.

EP. 1 Understanding Myelodysplastic Syndromes (MDS): Diagnosis, Classification, and Risk Assessment

2 KOLs are featured in this series.

EP. 2 Navigating the Heterogeneity of LR-MDS: Importance of Molecular Testing & Risk Stratifying

2 KOLs are featured in this series.

EP. 3 Clinical Scenario 1: 76-Year-Old Man With Newly Diagnosed MDS With Symptomatic Anemia, RS Positive

2 KOLs are featured in this series.

EP. 4 Tailoring Treatment for LR-MDS: Patient Factors, Treatment Goals, and Patient Outcomes

2 KOLs are featured in this series.

EP. 5 First-Line Luspatercept in LR-MDS: A Deep Dive Into the COMMANDS Trial and Clinical Implications in the Real-Life Practice Setting

2 KOLs are featured in this series.

EP. 6 Managing Luspatercept Therapy: Dosing, Adverse Effects, and Monitoring

2 KOLs are featured in this series.

EP. 7 Second-Line LR- MDS Setting: Treatment Options and Considerations

2 KOLs are featured in this series.

EP. 8 Patient Profile: 66-Year-Old Woman with Newly Diagnosed LR-MDS, RS Negative

2 KOLs are featured in this series.

EP. 9 Luspatercept Role in the RS-Negative Population and Expert Perspectives on the Role of EPO Levels

2 KOLs are featured in this series.

EP. 10 First-Line ESA vs Luspatercept in LR-MDS: Choosing the Most Appropriate Treatment Option for Each Individual Patient

2 KOLs are featured in this series.

EP. 11 Imetelstat and IMerge Trial Review

2 KOLs are featured in this series.

EP. 12 Looking Ahead in LR-MDS: Future Agents and/or Combination Strategies

2 KOLs are featured in this series.

EP. 13 The Future of Lower-Risk MDS: Closing Thoughts and Unmet Needs

Video content above is prompted by the following:

What is your dosing strategy for luspatercept in your clinical practice?
Please comment on Patel K, et al. Real-world luspatercept dose escalation and outcomes. EHA 2024 abstract.
Please describe some potential treatment-related adverse events associated with luspatercept that you’ve observed in your clinical practice.
How do you manage fatigue, hypertension, and diarrhea?
What labs do you monitor and recheck for if you are concerned that this patient is relapsing?
Resource links: DeZern AE, et al. Correlation between PB and BMBx mutations from national MDS study. ASH 2023 abstract.

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