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Distinctive Features of Male Breast Cancer Identified

Jason Harris
Published: Thursday, Apr 05, 2018

Suleiman Alfred Massarweh, MD
Suleiman Alfred Massarweh, MD
An analysis of clinical characteristics, gene expression, and 21-gene Breast Recurrence Score (RS) results identified distinctive biologic features of breast cancer in men, and also suggested that that RS testing may have an important prognostic role for both men and women.

“In addition to the biologic distinctions observed for breast cancer in men versus women, our study shows that both men and women with lower RS results have low mortality from ER-positive breast cancer, and many can be spared the risks associated with overtreatment, particularly from chemotherapy,” first author Suleiman Alfred Massarweh, MD, associate professor of medicine-oncology at the Stanford University Medical Center, and colleagues wrote. “Although there are limitations to our study, it may be appropriate to limit the use of chemotherapy in appropriately selected patients with RS 0-30, including those with 1-3LN.”
Massarweh SA, Sledge GW, Miller DP, et al. Molecular characterization and mortality from breast cancer in men [published online March 27, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.76.8861.

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