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Efforts Continue to Expand Immunotherapy in CRC

Danielle Bucco
Published: Monday, Nov 13, 2017

Johanna C. Bendell, MD

Johanna C. Bendell, MD
Anti–PD-1 inhibitors are effective in treating patients with microsatellite-instability high (MSI-H) colorectal cancer (CRC), with the FDA approving pembrolizumab (Keytruda) and nivolumab (Opdivo) for use in this setting.

, Bendell, a medical oncologist at Sarah Cannon Research Institute, discussed the current and emerging treatment landscape of immunotherapy for patients with CRC.

OncLive: What are some of the immunotherapy advances in CRC?

Bendell: We have seen very exciting data for patients with MSI-H CRC. These are patients who have a higher rate of mutations than others. They are very responsive to immunotherapies. In fact, we have seen FDA approvals of pembrolizumab for patients with MSI-H cancers, as well as nivolumab for MSI-H CRC, which shows what the benefit of these agents can be for these patients with CRC.
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