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FDA Approves Frontline Daratumumab/VMP Combo for Multiple Myeloma

Silas Inman @silasinman
Published: Tuesday, May 08, 2018

Andrzej Jakubowiak, MD, PhD

Andrzej Jakubowiak, MD, PhD
The FDA has approved daratumumab (Darzalex) in combination with bortezomib (Velcade), melphalan, and prednisone (VMP) for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant (ASCT), based on findings from the ALCYONE study.

Baseline characteristics were similar between the two groups of patients. In the daratumumab arm, the median age was 71 years and 30% were ≥75 years of age. The ECOG performance status was 0 (22%), 1 (52%), and 2 (26%). Ten percent of patients had light chain myeloma, with the remainder being IgG (64%) and IgA (21%). The most common ISS stages were III (41%) and II (40%). Seventeen percent of patients were high-risk by cytogenetic profile.

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