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FDA Grants Capmatinib Breakthrough Designation in Frontline METex14-Mutated NSCLC

Gina Columbus @ginacolumbusonc
Published: Friday, Sep 06, 2019

The FDA has granted a breakthrough therapy designation to capmatinib (INC280) as a first-line treatment for patients with MET exon14 skipping (METex14)—mutated non–small cell lung cancer (NSCLC).1



  1. Novartis investigational lung cancer therapy capmatinib (INC280) granted FDA Breakthrough Therapy Designation for patients with MET-mutated advanced non-small cell lung cancer[news release]. Basel, Switzerland: Novartis. Published September 6, 2019. Accessed September 6, 2019.
  2. Wolf J, Setons T, Han J-Y, et al. Capmatinib (INC280) in METΔex14-mutated advanced non-small cell lung cancer (NSCLC): efficacy data from the phase II GEOMETRY mono-1 study. J Clin Oncol. 2019;37(suppl; abstr 9004). doi: 10.1200/JCO.2019.37.15_suppl.9004.

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