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FDA Grants LN-145 Breakthrough Designation for Cervical Cancer

Jason M. Broderick @jasoncology
Published: Friday, May 24, 2019

The FDA has granted a breakthrough therapy designation to the tumor-infiltrating lymphocyte (TIL) therapy LN-145 for the treatment of patients with recurrent, metastatic, or persistent cervical cancer with disease progression on or after chemotherapy, according to Iovance Biotherapeutics, the manufacturer of the treatment.


Jazaeri AA, Zsiros E, Amaria RN, et al. Safety and efficacy of adoptive cell transfer using autologous tumor infiltrating lymphocytes (LN-145) for treatment of recurrent, metastatic, or persistent cervical carcinoma.  J Clin Oncol. 2019;37 (suppl; abstr 2538).

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