Ian W. Flinn, MD, PhD
The FDA approval of axicabtagene ciloleucel (axi-cel; Yescarta) in October 2017 for patients with non-Hodgkin lymphoma was one of the most exciting advancements in years for the lymphoma community.
Investigators are building on this breakthrough by exploring combination regimens with the CAR T-cell therapy. Results from the phase I/II ZUMA-6 trial presented at the 2017 ASH Annual Meeting showed that the combination of axi-cel with the PD-L1 inhibitor atezolizumab (Tecentriq) was highly active with a manageable safety profile in patients with refractory diffuse large B-cell lymphoma (DLBCL).
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