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Frontline Atezolizumab Plus Carboplatin/Nab-Paclitaxel Approved in Europe for Nonsquamous NSCLC

Jason M. Broderick @jasoncology
Published: Friday, Sep 06, 2019

Sandra Horning, MD, chief medical officer and head of Global Product Development, Roche

Sandra Horning, MD

The European Commission has approved atezolizumab (Tecentriq) for use in combination with carboplatin and nab-paclitaxel (Abraxane) for the first-line treatment of adult patients with advanced, nonsquamous non–small cell lung cancer (NSCLC) who do not have EGFR or ALK molecular aberrations, according to Roche (Genentech) the developer of the PD-L1 inhibitor.1

In the United States, the FDA is scheduled to make an approval decision on this atezolizumab regimen by December 2, 2019.


  1. European Commission approves Roche's new Tecentriq-based combination therapy as an initial treatment for most common form of advanced lung cancer. Roche. Published September 6, 2019. Access September 6, 2019.
  2. Cappuzzo F, McCleod M, Hussein M, et al. IMpower130: progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with or without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC. Ann Oncol. 2018;29(supp 8, abstr LBA53). doi: 10.1093/annonc/mdy424.065.

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