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Frontline Ibrutinib Plus Obinutuzumab Improves PFS in Phase III CLL Trial

Jason M. Broderick @jasoncology
Published: Thursday, May 24, 2018

John Gribben, MD

John Gribben, MD
Frontline treatment with the combination of ibrutinib (Imbruvica) and obinutuzumab (Gazyva) improved progression-free survival (PFS) compared with chlorambucil plus obinutuzumab in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), according to topline results from the phase III iLLUMINATE (PCYC-1130) trial.

“They’ve reported on the patients up until that first endpoint with the combination of ibrutinib and obinutuzumab. They also reported the universally successful outcomes with a 100% response rate. But they did note that not all patients, or not many patients, achieved that MRD negativity—I think it was about 10% or so. So, they did note that most of the patients still needed to receive chemoimmunotherapy afterwards with the goal of achieving MRD negativity. I do think that this study is still successful in showing the feasibility of that combination and the safety of that combination, as well as that the combination did achieve high response rates.”
Michallet AS, Dilhuydy MS, Subtil F, et al. Phase II, multicenter trial, exploring “chemo-sparing” strategy associating obinutuzumab + ibrutinib followed by a MRD driven strategy, in previously untreated symptomatic medically fit chronic lymphocytic leukemia patients (CLL): preliminary results of the induction phase of the Icll-07 filo study. Presented at: the 59th ASH Annual Meeting and Exposition; December 9-12, 2017; Atlanta, GA. Abstract 497. 

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