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Japan Approves Pembrolizumab for Urothelial Carcinoma

Jason M. Broderick @jasoncology
Published: Tuesday, Jan 02, 2018

Dr. Roy Baynes

Roy Baynes, MD, PhD
The Japanese Ministry of Health, Labor and Welfare has approved the use of pembrolizumab (Keytruda) for the treatment of patients with radically unresectable urothelial carcinoma who progressed after cancer chemotherapy, according to Merck, the manufacturer of the PD-1 inhibitor.

Patients who received pembrolizumab had fewer toxicities than those treated with chemotherapy. The incidence of treatment-related adverse events (AEs) was lower with pembrolizumab compared with chemotherapy, respectively, for any grade (60.9% vs 90.2%) and for AEs of grade 3-5 severity (15.0% vs 49.4%).

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