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Liso-Cel Highly Active in Relapsed/Refractory DLBCL

Danielle Bucco
Published: Monday, Jan 29, 2018

David Maloney, MD, PhD

David Maloney, MD, PhD
For patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), treatment with the CD19-targeted chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel (liso-cel, formally known as JCAR017) demonstrated a complete response (CR) rate of 63% and an objective response rate (ORR) of 81%, according to findings from the phase I TRANSCEND trial.1

Several data sets from TRANSCEND were presented during the 2017 ASH Annual Meeting. At the 3-month assessment for the dose being used in an ongoing pivotal trial for liso-cel, the ORR was 74% with a CR rate of 68%. By month 6, the ORR and CR rates were both 50% in this group. Regarding safety, only 30% of patients experienced cytokine release syndrome (CRS). Neurotoxicity at any grade developed in 14 patients, including 10 with grade 3/4.2
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