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Nivolumab/Ipilimumab Combo Approved in Europe for Frontline RCC

Jason M. Broderick and Gina Columbus
Published: Tuesday, Jan 15, 2019

Bernard Escudier, MD

Bernard Escudier, MD
The European Commission has approved nivolumab (Opdivo) combined with low-dose ipilimumab (Yervoy) as a frontline treatment for patients with intermediate- and poor-risk advanced renal cell carcinoma (RCC), according to Bristol-Meyers Squibb (BMS), the developer of both immunotherapy agents.

The FDA approved the combination of nivolumab and ipilimumab as a frontline treatment for intermediate- and poor-risk patients with advanced RCC, also based on the CheckMate-214 data, in April 2018.
Motzer RJ, Tannir NM, McDermott DF, Frontera OA, et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N Eng J Med. 2018;378(14):1277-1290. doi: 10.1056/NEJMoa1712126.

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