James R. Mark, MD
Evidence suggests that androgen deprivation therapy (ADT) increases the risk of cardiovascular disease (CVD) for patients with prostate cancer. It is known that both prostate cancer risk and cardiovascular risk increases with age, but there is also an association between them, according to James R. Mark, MD, an assistant professor at the Sidney Kimmel Cancer Center of Thomas Jefferson University Hospital.
Better FSH control remains one of the benefits of GnRH antagonists, he added. Additionally, there is no microflare, which may prevent a delay in castration-resistant prostate cancer, less PSA progression at 1 year, and fewer cardiac events. However, although the data suggest an improvement in PSA control, this has not translated to an overall survival benefit, says Mark.
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