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Pathological Fractures Linked to Inferior OS in Adults With Osteosarcoma

Brittany Cote
Published: Tuesday, Feb 11, 2020

Pathological fractures in adult patients with high-grade osteosarcoma of the extremities potentially correlates with inferior overall survival (OS), according to results of a retrospective analysis published in the Journal of Clinical Oncology.1 However, this conclusion was not found in pediatric patients.

“These results confirm those published in several previous studies that concluded that pathologic fractures are a predictor for worse survival in osteosarcoma,” the authors concluded in the study. “A decreased survival rate and a higher occurrence of [local recurrence] in patients with pathologic fractures was also found by our group. This study showed a significantly lower survival rate for adults with [pathologic fractures] and no significant survival difference in children with and without [pathologic fractures], as did our present study.”
Kelley LM, Schlegel M, Hecker-Nolting S, et al. Pathological fracture and prognosis of high-grade osteosarcoma of the extremities: an analysis of 2,847 consecutive cooperative osteosarcoma study group (COSS) patients [published online ahead of print January 13, 2020]. J Clin Oncol. doi:10.1200/JCO.19.00827.

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