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Quizartinib Improves Survival in FLT3-ITD+ Relapsed/Refractory AML

Jason M. Broderick @jasoncology
Published: Tuesday, May 08, 2018

Antoine Yver, MD, MSc

Antoine Yver, MD, MSc
Quizartinib improved overall survival (OS) compared with chemotherapy in patients with FLT3-ITD–positive relapsed/refractory acute myeloid leukemia (AML) after first-line treatment with or without hematopoietic stem cell transplantation (HSCT), according to findings from the phase III QuANTUM-R study.

mutation–positive relapsed or refractory AML.
Cortes JE, Kantarjian H, Foran JM, et al. Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status. J Clin Oncol. 2013;31(29):3681-3687. doi: 10.1200/JCO.2013.48.8783.

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