The development of high-grade acute graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation (HSCT) poses the highest risk for transplant-associated thrombotic microangiopathy (TA-TMA) in pediatric patients, according to retrospective results presented at the 2019 European Society for Blood and Marrow Transplantation Annual Meeting.1
“TA-TMA might represent a form of vascular acute GVHD; therefore, continuing control of acute GVHD, including the use of calcineurin inhibitors, may be important to prevent worsening of TA-TMA associated with GVHD,” Elfeky remarked.
- Elfeky R, Lucchini G, Lum SH, et al. New insights into risk factors for transplant-associated thrombotic microangiopathy (TA-TMA) in paediatric HSCT. Presented at: 2019 European Society for Blood and Marrow Transplantation Annual Meeting; March 24 to 27, 2019; Frankfurt, Germany. Abstract B287.
- Jodele S, Khoury JC, Goebel J, et al. Clinical utility of diagnostic criteria for hematopoietic stem cell transplant (HSCT)-associated thrombotic microangiopathy (TMA): a prospective single center study. Biol Blood Marrow Transp. 2013;19(2):S249. doi: 10.1016/j.bbmt.2012.11.327.
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