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Sequencing Questions Remain in Prostate Cancer Paradigm

Danielle Bucco
Published: Tuesday, Feb 13, 2018

Christopher J. Sweeney, MBBS

Christopher J. Sweeney, MBBS
The FDA recently expanded the approval of abiraterone acetate (Zytiga) to include the treatment of patients with metastatic high-risk castration-sensitive prostate cancer, based on findings from the phase III LATITUDE trial.

, Christopher Sweeney, MBBS, a medical oncologist at Dana-Farber Cancer Institute, discussed the role of abiraterone for patients with hormone-sensitive prostate cancer, and what physicians should consider when choosing between abiraterone and docetaxel.

OncLive: How do you determine whether to administer docetaxel or abiraterone to patients with prostate cancer?

Sweeney: Determining between abiraterone and docetaxel is a challenge, as both drugs work well. Abiraterone is an easier drug for most patients to tolerate because it is a hormonal therapy. Docetaxel also has activity, but it has a higher treatment burden.
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