Opinion|Videos|March 6, 2025
A 76-Year-Old Woman With Locally Advanced Unresectable Stage III EGFRm NSCLC
A 76-year-old woman with EGFR exon 19–positive adenocarcinoma and N3 disease undergoes chemoradiotherapy followed by osimertinib after a multidisciplinary evaluation and biomarker testing.
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Episodes in this series
Video content above is prompted by the following:
- Briefly provide comments and perspectives on this patient case.
- How may your treatment approach differ for the patient in case 2 if they had presented with an ALK vs EGFR alteration?
- Prior to this year, what was your approach in patients with unresectable stage III disease if biomarker testing resulted as positive for EGFR mutation (EGFRm)?
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The phase 3 REZILIENT3 trial met its primary end point at a pre-specified interim analysis, with a median PFS of 14.5 months and a 65.0% ORR.
The FDA has cleared an sNDA updating the taletrectinib (Ibtrozi) label with new DOR data in TKI-naive patients with locally advanced or metastatic ROS1-positive NSCLC.
Cesalatamig earned FDA fast track designation for NSCLC that progressed after immunotherapy and platinum-based chemotherapy.
The phase 2 AMIGO-1 trial met its end point, with an 18-month PFS rate of 66.7% for first-line amivantamab, lazertinib, and pemetrexed in EGFR-mutant NSCLC.
First-line osimertinib plus gefitinib produced an 82.1% response rate and blocked second-site EGFR resistance mutations, but missed feasibility criteria.
KST-6051 received FDA fast track designation for KRAS-mutant solid tumors.
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