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Opinion|Videos|March 6, 2025

A 76-Year-Old Woman With Locally Advanced Unresectable Stage III EGFRm NSCLC

A 76-year-old woman with EGFR exon 19–positive adenocarcinoma and N3 disease undergoes chemoradiotherapy followed by osimertinib after a multidisciplinary evaluation and biomarker testing.

Episodes in this series

EP. 1 Defining Resectability in Stage III NSCLC: Addressing Key Controversies

EP. 1 Defining Resectability in Stage III NSCLC: Addressing Key Controversies

EP. 2 Multidisciplinary Strategies for Optimizing Care in Unresectable Stage III NSCLC

EP. 2 Multidisciplinary Strategies for Optimizing Care in Unresectable Stage III NSCLC

EP. 3 Optimizing Biomarker Testing for Unresectable Stage III NSCLC

EP. 3 Optimizing Biomarker Testing for Unresectable Stage III NSCLC

EP. 4 Overcoming Barriers to Biomarker Testing in Unresectable NSCLC: Strategies for Improved Access and Implementation

EP. 4 Overcoming Barriers to Biomarker Testing in Unresectable NSCLC: Strategies for Improved Access and Implementation

EP. 5 Tailoring Chemoradiotherapy Approaches in Unresectable Stage III NSCLC

EP. 5 Tailoring Chemoradiotherapy Approaches in Unresectable Stage III NSCLC

EP. 6 Consolidation Durvalumab in Unresectable Stage III NSCLC: Management Strategies and the Role of ctDNA

EP. 6 Consolidation Durvalumab in Unresectable Stage III NSCLC: Management Strategies and the Role of ctDNA

EP. 7 Assessment and Management Strategies for Pneumonitis in Durvalumab Consolidation Post Chemoradiotherapy

EP. 7 Assessment and Management Strategies for Pneumonitis in Durvalumab Consolidation Post Chemoradiotherapy

EP. 8 Exploring the Role of SBRT in Unresectable NSCLC: Patient Selection and Trial Insights

EP. 8 Exploring the Role of SBRT in Unresectable NSCLC: Patient Selection and Trial Insights

EP. 9 A 76-Year-Old Woman With Locally Advanced Unresectable Stage III EGFRm NSCLC

EP. 9 A 76-Year-Old Woman With Locally Advanced Unresectable Stage III EGFRm NSCLC

EP. 10 Expert Insights on the LAURA Trial: Osimertinib After CRT in Unresectable Stage III EGFRm NSCLC as a New Standard of Care

EP. 10 Expert Insights on the LAURA Trial: Osimertinib After CRT in Unresectable Stage III EGFRm NSCLC as a New Standard of Care

EP. 11 Key Takeaways From the PACIFIC-2 Trial: The Role of Concurrent Immunotherapy With CRT

EP. 11 Key Takeaways From the PACIFIC-2 Trial: The Role of Concurrent Immunotherapy With CRT

EP. 12 Closing Thoughts and Clinical Pearls: Future Perspectives in NSCLC

EP. 12 Closing Thoughts and Clinical Pearls: Future Perspectives in NSCLC

Video content above is prompted by the following:

Briefly provide comments and perspectives on this patient case.
How may your treatment approach differ for the patient in case 2 if they had presented with an ALK vs EGFR alteration?
Prior to this year, what was your approach in patients with unresectable stage III disease if biomarker testing resulted as positive for EGFR mutation (EGFRm)?

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