Opinion|Videos|March 6, 2025
Tailoring Chemoradiotherapy Approaches in Unresectable Stage III NSCLC
This segment transitions to discussing the management of unresectable non–small cell lung cancer (NSCLC), focusing on the distinctions between concurrent and sequential chemoradiation. It highlights patient selection, treatment tolerability, the role of advanced radiation technologies, and considerations for minimizing adverse effects while ensuring optimal outcomes.
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Episodes in this series
Video content above is prompted by the following:
- How do you select patients with unresectable stage 3 NSCLC for sequential vs concurrent chemoradiotherapy (cCRT)? How do available data help inform your treatment decision?
- PACIFIC: 5-year follow-up data
- PACIFIC-R
- PACIFIC-6
- How do you manage patients not suitable for cCRT?
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The phase 3 REZILIENT3 trial met its primary end point at a pre-specified interim analysis, with a median PFS of 14.5 months and a 65.0% ORR.
The FDA has cleared an sNDA updating the taletrectinib (Ibtrozi) label with new DOR data in TKI-naive patients with locally advanced or metastatic ROS1-positive NSCLC.
Cesalatamig earned FDA fast track designation for NSCLC that progressed after immunotherapy and platinum-based chemotherapy.
The phase 2 AMIGO-1 trial met its end point, with an 18-month PFS rate of 66.7% for first-line amivantamab, lazertinib, and pemetrexed in EGFR-mutant NSCLC.
First-line osimertinib plus gefitinib produced an 82.1% response rate and blocked second-site EGFR resistance mutations, but missed feasibility criteria.
KST-6051 received FDA fast track designation for KRAS-mutant solid tumors.
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