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Opinion|Videos|August 21, 2024

ADCs in Breast Cancer: Mechanism of Action, and Components

Author(s)Hope S. Rugo, MD, FASCO, Aditya Bardia, MD, MPH, FASCO

Medical experts discuss the distinct mechanisms and components of different antibody-drug conjugates (ADCs), including the drug, antibody, and linker, and how these components contribute to the mechanisms of ADC-related toxicities.

Episodes in this series

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 5 Navigating SG-related Diarrhea

EP. 5 Navigating SG-related Diarrhea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 7 Overview of Cardiotoxicity Risk with T-DXd and Monitoring Strategies along with Anti-Nausea strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 8 Clinical Management Considerations: Pneumonitis associated with T-DXd

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 9 Expert Perspectives: T-DM1 Adverse Events Overview and Management Strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 10 Role of Multidisciplinary Team in the Management of Patients Receiving ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 11 Future Perspectives on ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 12 Expert Insights: Investigational ADCs Safety Profiles

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 13 Key Takeaways and Clinical Practice Pearls in the Treatment of Patients with Breast Cancer Receiving ADCs

Video content above is prompted by the following:

What are the different mechanisms between these antibody-drug conjugates (ADCs), as well as the different components that make up these ADCs (ie, drug, antibody, linker)?
Please briefly comment on how the different ADC components relate to the mechanism of some of the ADC-related toxicities.

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