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Opinion|Videos|September 11, 2024

Overview of Cardiotoxicity Risk with T-DXd and Monitoring Strategies along with Anti-Nausea strategies

Author(s)Hope Rugo, MD, Aditya Bardia, MD, MPH, FASCO

Experts on breast cancer discuss the potential adverse events related to trastuzumab deruxtecan (T-DXd).

Episodes in this series

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 5 Navigating SG-related Diarrhea

EP. 5 Navigating SG-related Diarrhea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 7 Overview of Cardiotoxicity Risk with T-DXd and Monitoring Strategies along with Anti-Nausea strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 8 Clinical Management Considerations: Pneumonitis associated with T-DXd

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 9 Expert Perspectives: T-DM1 Adverse Events Overview and Management Strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 10 Role of Multidisciplinary Team in the Management of Patients Receiving ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 11 Future Perspectives on ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 12 Expert Insights: Investigational ADCs Safety Profiles

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 13 Key Takeaways and Clinical Practice Pearls in the Treatment of Patients with Breast Cancer Receiving ADCs

Video content above is prompted by the following:

Can you describe the cardiotoxicity risk with T-DXd and the mechanism behind cardiovascular toxicity?
Please comment on your monitoring strategy for cardiotoxicity with T-DXd.
What patient symptoms do you monitor for? What are your left ventricular ejection fraction cutoffs to initiate, hold/delay, and discontinue therapy?

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