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Opinion|Videos|September 25, 2024

Expert Insights: Investigational ADCs Safety Profiles

Author(s)Hope S. Rugo, MD, FASCO, Aditya Bardia, MD, MPH, FASCO

Panelists discuss how, despite the investigational status of agents like patritumab deruxtecan (HER3-DXd) and datopotamab deruxtecan (Dato-DXd), it’s crucial for community oncologists to be aware of the treatment-related adverse effects (TRAEs) associated with these therapies and to consider effective management strategies as reported in clinical trials.

Episodes in this series

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 1 Overview of Current ADCs in Breast Cancer

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 2 ADCs in Breast Cancer: Mechanism of Action, and Components

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 3 Overview of SG-Related Neutropenia Rates in Real-Life Setting and in Clinical Trials

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 4 Expert Perspectives on the Management of SG-Related Neutropenia

EP. 5 Navigating SG-related Diarrhea

EP. 5 Navigating SG-related Diarrhea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

EP. 6 Expert Insights: SG Adverse Events Management including Alopecia & Nausea

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 7 Overview of Cardiotoxicity Risk with T-DXd and Monitoring Strategies along with Anti-Nausea strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 8 Clinical Management Considerations: Pneumonitis associated with T-DXd

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 9 Expert Perspectives: T-DM1 Adverse Events Overview and Management Strategies

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 10 Role of Multidisciplinary Team in the Management of Patients Receiving ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 11 Future Perspectives on ADCs in Breast Cancer

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 12 Expert Insights: Investigational ADCs Safety Profiles

Hope Rugo, MD, FASCO, and Aditya Bardia, MD, MPH, FASCO

EP. 13 Key Takeaways and Clinical Practice Pearls in the Treatment of Patients with Breast Cancer Receiving ADCs

Video content above is prompted by the following:

While these agents are still investigational, and their safety profiles have not been officially established…
Can you comment on any pertinent treatment-related adverse effects (TRAEs) associated with patritumab deruxtecan (HER3-DXd) reported in these clinical trials that the community oncologists should be aware of and your respective management strategies?
Please comment on any pertinent TRAEs associated with datopotamab deruxtecan (Dato-DXd) reported in these clinical trials that the community oncologists should be aware of and your respective management strategies.

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