
Opinion|Videos|September 25, 2024
Expert Insights: Investigational ADCs Safety Profiles
Panelists discuss how, despite the investigational status of agents like patritumab deruxtecan (HER3-DXd) and datopotamab deruxtecan (Dato-DXd), it’s crucial for community oncologists to be aware of the treatment-related adverse effects (TRAEs) associated with these therapies and to consider effective management strategies as reported in clinical trials.
Advertisement
Episodes in this series

Video content above is prompted by the following:
- While these agents are still investigational, and their safety profiles have not been officially established…
- Can you comment on any pertinent treatment-related adverse effects (TRAEs) associated with patritumab deruxtecan (HER3-DXd) reported in these clinical trials that the community oncologists should be aware of and your respective management strategies?
- Please comment on any pertinent TRAEs associated with datopotamab deruxtecan (Dato-DXd) reported in these clinical trials that the community oncologists should be aware of and your respective management strategies.
Advertisement
Related to this article

The 510(k) clearance covers an MRI-derived AI risk score for stage I to IIIA disease; the high-risk category carried an HR of 2.81 for recurrence.

The top 5 OncLive TV videos of the week cover insights in multiple myeloma, HR+ breast cancer, CAR T-cell therapy, CLL, and oral SERDs.

Nunnery and Bond discuss how patients and advocates can navigate second opinions, mental health support, and the long-term effects of cancer treatment.

Invikafusp alfa now holds fast track status across TMB-H solid tumors that progressed after prior therapy, including checkpoint inhibition.

Matthew P. Goetz, MD, explores menopausal status, recurrence risk, and adjuvant CDK4/6 inhibitor selection in HR-positive breast cancer.

Matthew P. Goetz, MD, explores first-line treatment selection, emerging targeted therapies, and unmet sequencing needs in metastatic breast cancer.

Readers share their opinions on some of the most talked-about breast cancer abstracts they’re looking forward to seeing at ESMO 2026.
Advertisement
Advertisement
Trending on OncLive
1
FDA Approves Dostarlimab for dMMR/MSI-H Locally Advanced Rectal Cancer
2
VOLGA, DASL-HiCaP Data Highlight Key Genitourinary Cancer Presentations Arriving at ESMO 2026
3
FDA Clears TumorSight Risk, an MRI-Derived AI Recurrence Tool for HR+, HER2– Breast Cancer
4
Japan Approves On-Body Injector for Subcutaneous Isatuximab in Multiple Myeloma
5

