
Opinion|Videos|March 31, 2026
Approaching Frontline Therapy in HER2-Mutant NSCLC
Author(s)Martin Dietrich, MD, PhD, Ticiana A. Leal, MD
Martin F. Dietrich, MD, PhD, and Ticiana Leal, MD, discuss frontline therapy approaches in HER2-mutant non–small cell lung cancer and the evolving role of chemoimmunotherapy.
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Episodes in this series

Martin F. Dietrich, MD, PhD, and Ticiana Leal, MD, discuss current approaches to frontline therapy in HER2-mutant non–small cell lung cancer. Dietrich reviews the ongoing role of chemotherapy with or without immunotherapy, particularly in the absence of upfront targeted options. Leal highlights considerations for deferring HER2-directed therapies to later lines and how these decisions are framed in clinical discussions with patients.
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