Opinion|Videos|March 31, 2026
Navigating TKI Selection in HER2-Mutant NSCLC
Author(s)Martin Dietrich, MD, PhD, Ticiana A. Leal, MD
Martin F. Dietrich, MD, PhD, and Ticiana Leal, MD, discuss factors that inform sevabertinib and zongertinib treatment selection in HER2-mutant NSCLC.
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Martin F. Dietrich, MD, PhD, and Ticiana Leal, MD, explore factors influencing selection between HER2-directed tyrosine kinase inhibitors such as sevabertinib and zongertinib. Dietrich compares efficacy and safety profiles across available agents, noting how toxicity considerations may drive individualized treatment choices. Leal emphasizes the importance of tailoring therapy based on patient comorbidities and tolerability to optimize outcomes.
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