Best Strategies for Sequencing Regorafenib in mCRC
Considerations for how to sequence therapy with regorafenib for relapsed or refractory metastatic colorectal cancer based on the REVERCE II study.
EP: 1.Initial Strategies for Assessing and Treating mCRC
EP: 2.Optimizing mCRC Treatment: Decision-Making With Patients
EP: 3.Colorectal Cancer in a Younger Population
EP: 4.Applying Aggressive Therapy to Treat mCRC Up Front
EP: 5.Maintenance Therapy for Metastatic CRC
EP: 6.Preferences for Second-Line Therapy for mCRC
EP: 7.Second-Line Treatment of mCRC: Rechallenging Therapy
EP: 8.Treatments for BRAF-Mutated mCRC
EP: 9.BRAF-Mutated mCRC: Treating With the BEACON Regimen
EP: 10.Regorafenib as Later-Line Treatment for mCRC
EP: 11.TAS-102 for Refractory mCRC
EP: 12.Best Strategies for Sequencing Regorafenib in mCRC
EP: 13.Fruquintinib for Refractory mCRC
EP: 14.Biomarker Testing and Precision Medicine in mCRC
EP: 15.Frontline I-O Treatment for mCRC
EP: 16.Best Practices Surrounding IO Treatment for mCRC
EP: 17.Dual I-O Therapy for mCRC
EP: 18.Novel Combinations Being Investigated for mCRC Treatment
EP: 19.Novel Therapies for HER2-Expressing mCRC
EP: 20.Decisions for Sequencing Therapy for HER2-Expressing mCRC
EP: 21.Exciting Treatment Opportunities in mCRC
Tanios S. Bekaii-Saab, MD: Going back to this concept of sequencing, there were interesting data from our friends in Japan that suggested if you went with regorafenib first followed by an EGFR inhibitor, the survival outcome is more favorable vs doing the reverse. That data looked very impressive, although the study was cut short. Any thoughts? Do we need to duplicate these results in the United States? Does it matter?
John H. Strickler, MD: These were very intriguing data that came out of Japan, where they asked a question: What sequence is better for a patient who is KRAS wild type? At the time the study was run, they were testing KRAS. They randomized patients to receive the anti-EGFR therapy first followed by regorafenib or regorafenib first followed by the anti-EGFR therapy. They did see a survival advantage for those patients who received regorafenib before the anti-EGFR. That study was cut short, and we think it does need some additional validation in the United States, so that led to the REVERCE II trial. We are asking the same question in a US population because it could be very constructive if that’s positive here as well.
Transcript Edited for Clarity
