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Opinion|Videos|March 26, 2025

CAR-T in Second-Line DLBCL: When and for Whom?

Author(s)Caron A. Jacobson, MD, MMSc, Peter Riedell, MD

Experts discuss the use of chimeric antigen receptor T-cell (CAR T) therapies, specifically axicabtagene ciloleucel (axi-cel) and lisocabtagene maraleucel (liso-cel), in the second-line setting for patients with diffuse large B-cell lymphoma (DLBCL), focusing on patient selection and treatment frequency.

Episodes in this series

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

Video content above is prompted by the following:

In the second-line setting in DLBCL, we currently have axi-cel and liso-cel. How often and for which patients do you consider CAR T for specifically in the second-line settieng?

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